A population genetic approach to mapping neurological disorder genes using deep resequencing.

A population genetic approach to mapping neurological disorder genes using deep resequencing.

Deep resequencing of functional regions in human genomes is key to identifying potentially causal rare variants for complex disorders. Here, we present the results from a large-sample resequencing (n  =  285 patients) study of candidate genes coupled with population genetics and statistical methods...

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Bibliographic Details
Main Authors: Rachel A Myers, Ferran Casals, Julie Gauthier, Fadi F Hamdan, Jon Keebler, Adam R Boyko, Carlos D Bustamante, Amelie M Piton, Dan Spiegelman, Edouard Henrion, Martine Zilversmit, Julie Hussin, Jacklyn Quinlan, Yan Yang, Ronald G Lafrenière, Alexander R Griffing, Eric A Stone, Guy A Rouleau, Philip Awadalla
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3044677?pdf=render

Internet

http://europepmc.org/articles/PMC3044677?pdf=render

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