Generation and characterization of a mitotane-resistant adrenocortical cell line

Generation and characterization of a mitotane-resistant adrenocortical cell line

Mitotane is the only drug approved for the therapy of adrenocortical carcinoma (ACC). Its clinical use is limited by the occurrence of relapse during therapy. To investigate the underlying mechanisms in vitro, we here generated mitotane-resistant cell lines. After long-term pulsed treatment of HAC-1...

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Bibliographic Details
Main Authors: Eric Seidel, Gudrun Walenda, Clemens Messerschmidt, Benedikt Obermayer, Mirko Peitzsch, Paal Wallace, Rohini Bahethi, Taekyeong Yoo, Murim Choi, Petra Schrade, Sebastian Bachmann, Gerhard Liebisch, Graeme Eisenhofer, Dieter Beule, Ute I Scholl
Format: Article
Language:English
Published: Bioscientifica 2020-02-01
Series:Endocrine Connections
Subjects:
chemotherapy
adrenolytic
somatic mutations
cholesterol
lipids
soat
Online Access:https://ec.bioscientifica.com/view/journals/ec/9/2/EC-19-0510.xml

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https://ec.bioscientifica.com/view/journals/ec/9/2/EC-19-0510.xml

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