Enzyme promiscuity shapes adaptation to novel growth substrates

Enzyme promiscuity shapes adaptation to novel growth substrates

Abstract Evidence suggests that novel enzyme functions evolved from low‐level promiscuous activities in ancestral enzymes. Yet, the evolutionary dynamics and physiological mechanisms of how such side activities contribute to systems‐level adaptations are not well characterized. Furthermore, it remai...

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Bibliographic Details
Main Authors: Gabriela I Guzmán, Troy E Sandberg, Ryan A LaCroix, Ákos Nyerges, Henrietta Papp, Markus de Raad, Zachary A King, Ying Hefner, Trent R Northen, Richard A Notebaart, Csaba Pál, Bernhard O Palsson, Balázs Papp, Adam M Feist
Format: Article
Language:English
Published: Wiley 2019-04-01
Series:Molecular Systems Biology
Subjects:
adaptive evolution
enzyme promiscuity
genome‐scale modeling
systems biology
Online Access:https://doi.org/10.15252/msb.20188462

Internet

https://doi.org/10.15252/msb.20188462

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