Philanthotoxin-343 attenuates retinal and optic nerve injury, and protects visual function in rats with N-methyl-D-aspartate-induced excitotoxicity.

Philanthotoxin-343 attenuates retinal and optic nerve injury, and protects visual function in rats with N-methyl-D-aspartate-induced excitotoxicity.

Retinal ganglion cell (RGC) loss and optic neuropathy, both hallmarks of glaucoma, have been shown to involve N-methyl-D-aspartate receptor (NMDAR)-mediated excitotoxicity. This study investigated the neuroprotective effects of Philanthotoxin (PhTX)-343 in NMDA-induced retinal injury to alleviate en...

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Bibliographic Details
Main Authors: Muhammad Fattah Fazel, Izuddin Fahmy Abu, Mohamad Haiqal Nizar Mohamad, Renu Agarwal, Igor Iezhitsa, Nor Salmah Bakar, Norsham Juliana, Ian R Mellor, Henrik Franzyk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0236450

Internet

https://doi.org/10.1371/journal.pone.0236450

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