Glycogen synthase kinase-3 inhibition sensitizes pancreatic cancer cells to TRAIL-induced apoptosis.

Glycogen synthase kinase-3 inhibition sensitizes pancreatic cancer cells to TRAIL-induced apoptosis.

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) induces apoptosis in a variety of cancer cell lines with little or no effect on normal cells. However, its effect is limited as some cancers including pancreatic cancer show de novo resistance to TRAIL induced apoptosis. In this study w...

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Bibliographic Details
Main Authors: Shadi Mamaghani, Craig D Simpson, Pinjiang M Cao, May Cheung, Sue Chow, Bizhan Bandarchi, Aaron D Schimmer, David W Hedley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3400624?pdf=render

Internet

http://europepmc.org/articles/PMC3400624?pdf=render

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