GSKJ4 Protects Mice Against Early Sepsis via Reducing Proinflammatory Factors and Up-Regulating MiR-146a

GSKJ4 Protects Mice Against Early Sepsis via Reducing Proinflammatory Factors and Up-Regulating MiR-146a

Sepsis, defined as life-threatening organ dysfunction, is one of the most common causes of mortality in intensive care units with limited therapeutic options. However, the mechanism underlying the regulation of epigenetics on sepsis remains largely undefined. Here we showed that JMJD3, the histone l...

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Bibliographic Details
Main Authors: Yuchen Pan, Jiali Wang, Yaxian Xue, Jiaojiao Zhao, Dan Li, Shaolong Zhang, Kuanyu Li, Yayi Hou, Hongye Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
GSKJ4
JMJD3
sepsis
miR-146a
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02272/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02272/full

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