Different tau species lead to heterogeneous tau pathology propagation and misfolding

Different tau species lead to heterogeneous tau pathology propagation and misfolding

Abstract Tauopathies are a heterogeneous group of pathologies characterized by tau aggregation inside neurons. Most of them are sporadic but certain tauopathies rely on tau gene (MAPT) mutations. They particularly differ from one to another by their different neuropathological signatures e.g. lesion...

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Bibliographic Details
Main Authors: Simon Dujardin, Séverine Bégard, Raphaëlle Caillierez, Cédrick Lachaud, Sébastien Carrier, Sarah Lieger, Jose A. Gonzalez, Vincent Deramecourt, Nicole Déglon, Claude-Alain Maurage, Matthew P. Frosch, Bradley T. Hyman, Morvane Colin, Luc Buée
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Acta Neuropathologica Communications
Subjects:
Tau
Propagation
Isoforms
Misfolding
Alzheimer’s disease
Heterogeneity
Online Access:http://link.springer.com/article/10.1186/s40478-018-0637-7

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http://link.springer.com/article/10.1186/s40478-018-0637-7

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