Noninvasive prenatal diagnosis of fetal trisomy 18 and trisomy 13 by maternal plasma DNA sequencing.

Noninvasive prenatal diagnosis of fetal trisomy 18 and trisomy 13 by maternal plasma DNA sequencing.

Massively parallel sequencing of DNA molecules in the plasma of pregnant women has been shown to allow accurate and noninvasive prenatal detection of fetal trisomy 21. However, whether the sequencing approach is as accurate for the noninvasive prenatal diagnosis of trisomy 13 and 18 is unclear due t...

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Bibliographic Details
Main Authors: Eric Z Chen, Rossa W K Chiu, Hao Sun, Ranjit Akolekar, K C Allen Chan, Tak Y Leung, Peiyong Jiang, Yama W L Zheng, Fiona M F Lun, Lisa Y S Chan, Yongjie Jin, Attie T J I Go, Elizabeth T Lau, William W K To, Wing C Leung, Rebecca Y K Tang, Sidney K C Au-Yeung, Helena Lam, Yu Y Kung, Xiuqing Zhang, John M G van Vugt, Ryoko Minekawa, Mary H Y Tang, Jun Wang, Cees B M Oudejans, Tze K Lau, Kypros H Nicolaides, Y M Dennis Lo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3130771?pdf=render

Internet

http://europepmc.org/articles/PMC3130771?pdf=render

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