Application of An Improved HPLC-FL Method to Screen Serine Palmitoyl Transferase Inhibitors

Application of An Improved HPLC-FL Method to Screen Serine Palmitoyl Transferase Inhibitors

In this work, we reported the application and validation of an improved high-performance liquid chromatography method coupled with a fluorimetric detector (HPLC-FL) to screen the activity of two heterocyclic derivatives reported as serine palmitoyl transferase (SPT) inhibitors. The analytical condit...

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Bibliographic Details
Main Authors: Simone Bertini, Giuseppe Saccomanni, Sara Del Carlo, Maria Digiacomo, Claudia Gargini, Ilaria Piano, Giuseppe Matteo Campisi, Riccardo Ghidoni, Marco Macchia, Clementina Manera
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:Molecules
Subjects:
HPLC
serine palmitoyl transferase
SPT
screening
enzymatic assay
Online Access:https://www.mdpi.com/1420-3049/22/7/1198

Internet

https://www.mdpi.com/1420-3049/22/7/1198

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