Astrocyte-derived clusterin suppresses amyloid formation in vivo

Astrocyte-derived clusterin suppresses amyloid formation in vivo

Abstract Background Accumulation of amyloid-β (Aβ) peptide in the brain is a pathological hallmark of Alzheimer’s disease (AD). The clusterin (CLU) gene confers a risk for AD and CLU is highly upregulated in AD patients, with the common non-coding, protective CLU variants associated with increased e...

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Bibliographic Details
Main Authors: Aleksandra M. Wojtas, Jonathon P. Sens, Silvia S. Kang, Kelsey E. Baker, Taylor J. Berry, Aishe Kurti, Lillian Daughrity, Karen R. Jansen-West, Dennis W. Dickson, Leonard Petrucelli, Guojun Bu, Chia-Chen Liu, John D. Fryer
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Clusterin
Aβ
Amyloid plaques
Adeno-associated viral vectors
Haploinsufficiency
Online Access:https://doi.org/10.1186/s13024-020-00416-1

Internet

https://doi.org/10.1186/s13024-020-00416-1

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