Astrocyte-derived clusterin suppresses amyloid formation in vivo
Abstract Background Accumulation of amyloid-β (Aβ) peptide in the brain is a pathological hallmark of Alzheimer’s disease (AD). The clusterin (CLU) gene confers a risk for AD and CLU is highly upregulated in AD patients, with the common non-coding, protective CLU variants associated with increased e...
Main Authors: | Aleksandra M. Wojtas, Jonathon P. Sens, Silvia S. Kang, Kelsey E. Baker, Taylor J. Berry, Aishe Kurti, Lillian Daughrity, Karen R. Jansen-West, Dennis W. Dickson, Leonard Petrucelli, Guojun Bu, Chia-Chen Liu, John D. Fryer |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-11-01
|
Series: | Molecular Neurodegeneration |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13024-020-00416-1 |
Similar Items
-
Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation
by: Aleksandra M. Wojtas, et al.
Published: (2020-12-01) -
Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer’s disease neuropathology
by: Fading Chen, et al.
Published: (2021-01-01) -
Immunohistochemical expression of clusterin in colorectal carcinoma
by: Jalal Ali Jalal, et al.
Published: (2021-08-01) -
Investigation into the role of the extracellular chaperone, clusterin, in Aβ42 oligomer interactions with mammalian cells
by: Hook, Sharon Clare
Published: (2014) -
Downregulation of Clusterin Expression in Human Testicular Seminoma
by: Bianjiang Liu, et al.
Published: (2013-11-01)