Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction

Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction

Abstract Background Alterations in cardiac energy metabolism contribute to the development and severity of heart failure (HF). In severe HF, overall mitochondrial oxidative metabolism is significantly decreased resulting in a reduced energy reserve. However, despite the high prevalence of HF with pr...

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Bibliographic Details
Main Authors: Natasha Fillmore, Jody L. Levasseur, Arata Fukushima, Cory S. Wagg, Wei Wang, Jason R. B. Dyck, Gary D. Lopaschuk
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Molecular Medicine
Subjects:
Mitochondria
Fatty acid oxidation
Energy metabolism
Diastolic dysfunction
Cardiac hypertrophy
Online Access:http://link.springer.com/article/10.1186/s10020-018-0005-x

Internet

http://link.springer.com/article/10.1186/s10020-018-0005-x

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