3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors.

3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors.

Aberrant activation of the Wnt signalling pathway is required for tumour initiation and survival in the majority of colorectal cancers. The development of inhibitors of Wnt signalling has been the focus of multiple drug discovery programs targeting colorectal cancer and other malignancies associated...

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Bibliographic Details
Main Authors: Luned M Badder, Andrew J Hollins, Bram Herpers, Kuan Yan, Kenneth B Ewan, Mairian Thomas, Jennifer R Shone, Delyth A Badder, Marc Naven, Kevin E Ashelford, Rachel Hargest, Alan R Clarke, Christina Esdar, Hans-Peter Buchstaller, J Mark Treherne, Sylvia Boj, Bahar Ramezanpour, Dirk Wienke, Leo S Price, Paul H Shaw, Trevor C Dale
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0235319

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https://doi.org/10.1371/journal.pone.0235319

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