Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF

Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF

Small molecules stabilising a distorted TNF trimer can inhibit TNF signaling, but the underlying mechanism is unclear. Here, the authors characterize the inhibitor-bound TNF-receptor complex structurally and biochemically, showing that the inhibitors alter TNF-receptor binding stoichiometry and clus...

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Bibliographic Details
Main Authors: David McMillan, Carlos Martinez-Fleites, John Porter, David Fox, Rachel Davis, Prashant Mori, Tom Ceska, Bruce Carrington, Alastair Lawson, Tim Bourne, James O’Connell
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20828-3

Internet

https://doi.org/10.1038/s41467-020-20828-3

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