LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes.

LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes.

Polarization of hepatocytes is manifested by bile canalicular network formation and activation of LKB1 and AMPK, which control cellular energy metabolism. The bile acid, taurocholate, also regulates development of the canalicular network through activation of AMPK. In the present study, we used coll...

Full description

Bibliographic Details
Main Authors: László Homolya, Dong Fu, Prabuddha Sengupta, Michal Jarnik, Jean-Pierre Gillet, Lynn Vitale-Cross, J Silvio Gutkind, Jennifer Lippincott-Schwartz, Irwin M Arias
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3958433?pdf=render

Internet

http://europepmc.org/articles/PMC3958433?pdf=render

Similar Items