A human liver chimeric mouse model for non-alcoholic fatty liver disease

A human liver chimeric mouse model for non-alcoholic fatty liver disease

Background & Aims: The accumulation of neutral lipids within hepatocytes underlies non-alcoholic fatty liver disease (NAFLD), which affects a quarter of the world’s population and is associated with hepatitis, cirrhosis, and hepatocellular carcinoma. Despite insights gained from both human a...

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Bibliographic Details
Main Authors: Beatrice Bissig-Choisat, Michele Alves-Bezerra, Barry Zorman, Scott A. Ochsner, Mercedes Barzi, Xavier Legras, Diane Yang, Malgorzata Borowiak, Adam M. Dean, Robert B. York, N. Thao N. Galvan, John Goss, William R. Lagor, David D. Moore, David E. Cohen, Neil J. McKenna, Pavel Sumazin, Karl-Dimiter Bissig
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:JHEP Reports
Subjects:
Non-alcoholic fatty liver disease
Steatosis
Lipid metabolism
Human disease modelling
Humanised mice
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555921000574

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http://www.sciencedirect.com/science/article/pii/S2589555921000574

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