Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer

Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer

Summary: MED1 (mediator subunit 1) co-amplifies with HER2, but its role in HER2-driven mammary tumorigenesis is still unknown. Here, we generate MED1 mammary-specific overexpression mice and cross them with mouse mammary tumor virus (MMTV)-HER2 mice. We observe significantly promoted onset, growth,...

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Bibliographic Details
Main Authors: Yongguang Yang, Marissa Leonard, Zhenhua Luo, Syn Yeo, Gregory Bick, Mingang Hao, Chunmiao Cai, Mahmoud Charif, Jiang Wang, Jun-Lin Guan, Elyse E. Lower, Xiaoting Zhang
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Subjects:
HER2
MED1
Jab1
cancer stem cell
tumor metastasis
therapeutic resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721001364

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http://www.sciencedirect.com/science/article/pii/S2211124721001364

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