Differential gene expression analysis tools exhibit substandard performance for long non-coding RNA-sequencing data

Differential gene expression analysis tools exhibit substandard performance for long non-coding RNA-sequencing data

Abstract Background Long non-coding RNAs (lncRNAs) are typically expressed at low levels and are inherently highly variable. This is a fundamental challenge for differential expression (DE) analysis. In this study, the performance of 25 pipelines for testing DE in RNA-seq data is comprehensively eva...

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Bibliographic Details
Main Authors: Alemu Takele Assefa, Katrijn De Paepe, Celine Everaert, Pieter Mestdagh, Olivier Thas, Jo Vandesompele
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Genome Biology
Subjects:
RNA-seq
mRNA
lncRNA
Differential gene expression
Online Access:http://link.springer.com/article/10.1186/s13059-018-1466-5

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http://link.springer.com/article/10.1186/s13059-018-1466-5

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