Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.

Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.

A C1858T (R620W) variation in the PTPN22 gene encoding the tyrosine phosphatase LYP is a major risk factor for human autoimmunity. LYP is a known negative regulator of signaling through the T cell receptor (TCR), and murine Ptpn22 plays a role in thymic selection. However, the mechanism of action of...

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Bibliographic Details
Main Authors: Dennis J Wu, Wenbo Zhou, Sarah Enouz, Valeria Orrú, Stephanie M Stanford, Christian J Maine, Novella Rapini, Kristy Sawatzke, Isaac Engel, Edoardo Fiorillo, Linda A Sherman, Mitch Kronenberg, Dietmar Zehn, Erik Peterson, Nunzio Bottini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3911918?pdf=render

Internet

http://europepmc.org/articles/PMC3911918?pdf=render

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