Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3
Conjugative transfer of antibiotic resistance plasmid pCW3 in Clostridium perfringens is mediated by the tcp locus. Here, the authors identify a wHTH-type protein, TcpK, that is essential for efficient plasmid transfer and interacts with the plasmid oriT region in a unique manner.
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-09-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06096-2 |