Differentiation of Murine C2C12 Myoblasts Strongly Reduces the Effects of Myostatin on Intracellular Signaling

Differentiation of Murine C2C12 Myoblasts Strongly Reduces the Effects of Myostatin on Intracellular Signaling

Alongside in vivo models, a simpler and more mechanistic approach is required to study the effects of myostatin on skeletal muscle because myostatin is an important negative regulator of muscle size. In this study, myostatin was administered to murine (C2C12) and human (CHQ) myoblasts and myotubes....

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Bibliographic Details
Main Authors: Juulia H. Lautaoja, Satu Pekkala, Arja Pasternack, Mika Laitinen, Olli Ritvos, Juha J. Hulmi
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Biomolecules
Subjects:
coculture
follistatin
inflammation
MAPK
myotube
skeletal muscle
Online Access:https://www.mdpi.com/2218-273X/10/5/695

Internet

https://www.mdpi.com/2218-273X/10/5/695

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