Antigen receptor control of methionine metabolism in T cells

Antigen receptor control of methionine metabolism in T cells

Immune activated T lymphocytes modulate the activity of key metabolic pathways to support the transcriptional reprograming and reshaping of cell proteomes that permits effector T cell differentiation. The present study uses high resolution mass spectrometry and metabolic labelling to explore how mur...

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Bibliographic Details
Main Authors: Linda V Sinclair, Andrew JM Howden, Alejandro Brenes, Laura Spinelli, Jens L Hukelmann, Andrew N Macintyre, Xiaojing Liu, Sarah Thomson, Peter M Taylor, Jeffrey C Rathmell, Jason W Locasale, Angus I Lamond, Doreen A Cantrell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-03-01
Series:eLife
Subjects:
lymphocyte
T cell activation
nutrient uptake
methionine metabolism
proteomics
Online Access:https://elifesciences.org/articles/44210

Internet

https://elifesciences.org/articles/44210

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