A Novel LRRK2 Variant p.G2294R in the WD40 Domain Identified in Familial Parkinson’s Disease Affects LRRK2 Protein Levels

A Novel LRRK2 Variant p.G2294R in the WD40 Domain Identified in Familial Parkinson’s Disease Affects LRRK2 Protein Levels

<i>Leucine-rich repeat kinase 2</i> (<i>LRRK2</i>) is a major causative gene of late-onset familial Parkinson’s disease (PD). The suppression of kinase activity is believed to confer neuroprotection, as most pathogenic variants of <i>LRRK2</i> associated with PD e...

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Bibliographic Details
Main Authors: Jun Ogata, Kentaro Hirao, Kenya Nishioka, Arisa Hayashida, Yuanzhe Li, Hiroyo Yoshino, Soichiro Shimizu, Nobutaka Hattori, Yuzuru Imai
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
familial Parkinson’s disease
<i>LRRK2</i>
genetics
macrophage
loss-of-function
Online Access:https://www.mdpi.com/1422-0067/22/7/3708

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https://www.mdpi.com/1422-0067/22/7/3708

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