Designing bacterial signaling interactions with coevolutionary landscapes.

Designing bacterial signaling interactions with coevolutionary landscapes.

Selecting amino acids to design novel protein-protein interactions that facilitate catalysis is a daunting challenge. We propose that a computational coevolutionary landscape based on sequence analysis alone offers a major advantage over expensive, time-consuming brute-force approaches currently emp...

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Bibliographic Details
Main Authors: Ryan R Cheng, Ellinor Haglund, Nicholas S Tiee, Faruck Morcos, Herbert Levine, Joseph A Adams, Patricia A Jennings, José N Onuchic
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6101370?pdf=render

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http://europepmc.org/articles/PMC6101370?pdf=render

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