Cystitis-Related Bladder Pain Involves ATP-Dependent HMGB1 Release from Macrophages and Its Downstream H<sub>2</sub>S/Ca<sub>v</sub>3.2 Signaling in Mice

Cystitis-Related Bladder Pain Involves ATP-Dependent HMGB1 Release from Macrophages and Its Downstream H<sub>2</sub>S/Ca<sub>v</sub>3.2 Signaling in Mice

Cystitis-related bladder pain involves RAGE activation by HMGB1, and increased Ca<sub>v</sub>3.2 T-type Ca<sup>2+</sup> channel activity by H<sub>2</sub>S, generated by upregulated cystathionine-γ-lyase (CSE) in mice treated with cyclophosphamide (CPA). We, thus,...

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Bibliographic Details
Main Authors: Shiori Hiramoto, Maho Tsubota, Kaoru Yamaguchi, Kyoko Okazaki, Aya Sakaegi, Yuki Toriyama, Junichi Tanaka, Fumiko Sekiguchi, Hiroyasu Ishikura, Hidenori Wake, Masahiro Nishibori, Huy Du Nguyen, Takuya Okada, Naoki Toyooka, Atsufumi Kawabata
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
interstitial cystitis/bladder pain syndrome (IC/BPS)
cyclophosphamide (CPA)
high mobility group box 1 (HMGB1)
receptor for advanced glycation end products (RAGE)
Ca<sub>v</sub>3.2 T-type Ca<sup>2+</sup> channel
hydrogen sulfide (H<sub>2</sub>S)
Online Access:https://www.mdpi.com/2073-4409/9/8/1748

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https://www.mdpi.com/2073-4409/9/8/1748

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