Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood

Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood

Mutations in the ALS2 gene, which encodes alsin, cause autosomal recessive juvenile-onset amyotrophic lateral sclerosis (ALS2) and related conditions. Using both a novel monoclonal antibody and LacZ knock-in mice, we demonstrate that alsin is widely expressed in neurons of the CNS, including the cor...

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Bibliographic Details
Main Authors: Rebecca S. Devon, Claudia Schwab, Justin D. Topp, Paul C. Orban, Yu-zhou Yang, Terry D. Pape, Jeffrey R. Helm, Tara-Lynne Davidson, Daniel A. Rogers, Francois Gros-Louis, Guy Rouleau, Bruce F. Horazdovsky, Blair R. Leavitt, Michael R. Hayden
Format: Article
Language:English
Published: Elsevier 2005-03-01
Series:Neurobiology of Disease
Subjects:
ALS2
Alsin
ALS2CL
lacZ
Cerebellum
Endosome
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104002359

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http://www.sciencedirect.com/science/article/pii/S0969996104002359

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