LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis

Lipoma preferred partner (LPP) mediates TGFβ-induced breast cancer cell migration and invasion. Here the authors show that LPP is a Src-family kinase substrate that regulates the formation of protrusions of the plasma membrane -called invadopodia- required for breast cancer metastasis.

Bibliographic Details
Main Authors: Elaine Ngan, Konstantin Stoletov, Harvey W. Smith, Jessica Common, William J. Muller, John D. Lewis, Peter M. Siegel
Format: Article
Language:English
Published: Nature Publishing Group 2017-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15059