Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2

Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2

Liver and pancreas cells arise from a common endoderm progenitor in the embryo, but what regulates their cell fate is unclear. Here, the authors show that expression of the Three-Amino-acid-Loop-Extension (TALE) homeobox TG-interacting factor 2 (TGIF2) in hepatocytes reprogrammes the cells to a panc...

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Bibliographic Details
Main Authors: Nuria Cerdá-Esteban, Heike Naumann, Silvia Ruzittu, Nancy Mah, Igor M. Pongrac, Corinna Cozzitorto, Angela Hommel, Miguel A. Andrade-Navarro, Ezio Bonifacio, Francesca M. Spagnoli
Format: Article
Language:English
Published: Nature Publishing Group 2017-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14127

Internet

https://doi.org/10.1038/ncomms14127

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