Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors

Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors

Adaptive immune recognition is mediated by specific interactions between heterodimeric T cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to accurately predict TCR:pMHC interaction would have profound clinical, therapeutic and pharmaceutical applications. Herein, w...

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Bibliographic Details
Main Authors: Chloe H. Lee, Mariolina Salio, Giorgio Napolitani, Graham Ogg, Alison Simmons, Hashem Koohy
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
T cell cross reactivity
T cell specificity
epitope
antigen presentation
adaptive immune system
antigen specificity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.565096/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.565096/full

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