Vectored delivery of anti-SIV envelope targeting mAb via AAV8 protects rhesus macaques from repeated limiting dose intrarectal swarm SIVsmE660 challenge.

Gene based delivery of immunoglobulins promises to safely and durably provide protective immunity to individuals at risk of acquiring infectious diseases such as HIV. We used a rhesus macaque animal model to optimize delivery of naturally-arising, autologous anti-SIV neutralizing antibodies expresse...

Full description

Bibliographic Details
Main Authors:	Hugh C Welles, Madeleine F Jennewein, Rosemarie D Mason, Sandeep Narpala, Lingshu Wang, Cheng Cheng, Yi Zhang, John-Paul Todd, Jeffrey D Lifson, Alejandro B Balazs, Galit Alter, Adrian B McDermott, John R Mascola, Mario Roederer
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2018-12-01
Series:	PLoS Pathogens
Online Access:	https://doi.org/10.1371/journal.ppat.1007395

Internet

https://doi.org/10.1371/journal.ppat.1007395

Vectored delivery of anti-SIV envelope targeting mAb via AAV8 protects rhesus macaques from repeated limiting dose intrarectal swarm SIVsmE660 challenge.

Internet

Similar Items