A dual‐AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock‐out mice

A dual‐AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock‐out mice

Abstract Normal hearing and synaptic transmission at afferent auditory inner hair cell (IHC) synapses require otoferlin. Deafness DFNB9, caused by mutations in the OTOF gene encoding otoferlin, might be treated by transferring wild‐type otoferlin cDNA into IHCs, which is difficult due to the large s...

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Bibliographic Details
Main Authors: Hanan Al‐Moyed, Andreia P Cepeda, SangYong Jung, Tobias Moser, Sebastian Kügler, Ellen Reisinger
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:EMBO Molecular Medicine
Subjects:
deafness
gene therapy
hearing restoration
inner ear
inner hair cell
Online Access:https://doi.org/10.15252/emmm.201809396

Internet

https://doi.org/10.15252/emmm.201809396

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