RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland

RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland

RUNX2, a master regulator of osteogenesis, is oncogenic in the lymphoid lineage; however, little is known about its role in epithelial cancers. Upregulation of RUNX2 in cell lines correlates with increased invasiveness and the capacity to form osteolytic disease in models of breast and prostate canc...

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Bibliographic Details
Main Authors: Laura McDonald, Nicola Ferrari, Anne Terry, Margaret Bell, Zahra M. Mohammed, Clare Orange, Alma Jenkins, William J. Muller, Barry A. Gusterson, James C. Neil, Joanne Edwards, Joanna S. Morris, Ewan R. Cameron, Karen Blyth
Format: Article
Language:English
Published: The Company of Biologists 2014-05-01
Series:Disease Models & Mechanisms
Subjects:
RUNX2
Breast cancer
Transgenic model
Mammary development
Online Access:http://dmm.biologists.org/content/7/5/525

Internet

http://dmm.biologists.org/content/7/5/525

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