Familial Alzheimer’s Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis

Familial Alzheimer’s Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis

Summary: Mutations in presenilin 1 (PSEN1) or presenilin 2 (PSEN2), the catalytic subunit of γ-secretase, cause familial Alzheimer’s disease (fAD). We hypothesized that mutations in PSEN1 reduce Notch signaling and alter neurogenesis. Expression data from developmental and adult neurogenesis show re...

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Bibliographic Details
Main Authors: Charles Arber, Christopher Lovejoy, Lachlan Harris, Nanet Willumsen, Argyro Alatza, Jackie M. Casey, Georgie Lines, Caoimhe Kerins, Anika K. Mueller, Henrik Zetterberg, John Hardy, Natalie S. Ryan, Nick C. Fox, Tammaryn Lashley, Selina Wray
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cell Reports
Subjects:
Alzheimer’s disease
iPSC
organoid
neurogenesis
hippocampus
PSEN1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720316041

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http://www.sciencedirect.com/science/article/pii/S2211124720316041

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