Insulin directly stimulates mitochondrial glucose oxidation in the heart

Insulin directly stimulates mitochondrial glucose oxidation in the heart

Abstract Background Glucose oxidation is a major contributor to myocardial energy production and its contribution is orchestrated by insulin. While insulin can increase glucose oxidation indirectly by enhancing glucose uptake and glycolysis, it also directly stimulates mitochondrial glucose oxidatio...

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Bibliographic Details
Main Authors: Qutuba G. Karwi, Cory S. Wagg, Tariq R. Altamimi, Golam M. Uddin, Kim L. Ho, Ahmed M. Darwesh, John M. Seubert, Gary D. Lopaschuk
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Cardiovascular Diabetology
Subjects:
Glucose oxidation
Insulin signaling
Protein kinase B (akt)
Protein kinase C-delta (PKC-δ)
Glycogen synthase kinase-3 beta (GSK-3β)
Mitochondria
Online Access:https://doi.org/10.1186/s12933-020-01177-3

Internet

https://doi.org/10.1186/s12933-020-01177-3

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