Integrative Approach to Reveal Cell Type Specificity and Gene Candidates for Psoriatic Arthritis Outside the MHC

Integrative Approach to Reveal Cell Type Specificity and Gene Candidates for Psoriatic Arthritis Outside the MHC

We recently conducted a large association analysis to compare the genetic profiles between patients with psoriatic arthritis (PsA) and cutaneous-only psoriasis (PsC). Despite including over 7,000 genotyped patients, only the MHC achieved genome-wide significance. In this study, we hypothesized that...

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Bibliographic Details
Main Authors: Matthew T. Patrick, Philip E. Stuart, Kalpana Raja, Sunyi Chi, Zhi He, John J. Voorhees, Trilokraj Tejasvi, Johann E. Gudjonsson, J. Michelle Kahlenberg, Vinod Chandran, Proton Rahman, Dafna D. Gladman, Rajan P. Nair, James T. Elder, Lam C. Tsoi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Genetics
Subjects:
psoriatic arthritis
gene candidates
systems biology
epigenomics
GWAS
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00304/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00304/full

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