Hyodeoxycholic acid efficiently suppresses atherosclerosis formation and plasma cholesterol levels in mice

Hyodeoxycholic acid efficiently suppresses atherosclerosis formation and plasma cholesterol levels in mice

We examined the effect of hyodeoxycholic acid (HDCA) on plasma cholesterol levels and atherosclerosis in mice. In wild-type C57BL/6 mice, feeding increasing amounts of HDCA resulted in i) progressive decrease in dietary cholesterol absorption, ii) increased concentrations of HDCA in the gallbladder...

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Bibliographic Details
Main Authors: Ephraim Sehayek, Jennie G. Ono, Elizabeth M. Duncan, Ashok K. Batta, Gerald Salen, Sarah Shefer, Lien B. Neguyen, Kan Yang, Martin Lipkin, Jan L. Breslow
Format: Article
Language:English
Published: Elsevier 2001-08-01
Series:Journal of Lipid Research
Subjects:
bile acids
cholesterol absorption
colon cancer
dietary cholesterol
LDL-receptor knockout
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520315753

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http://www.sciencedirect.com/science/article/pii/S0022227520315753

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