Computer-Aided Discovery of Small Molecules Targeting the RNA Splicing Activity of hnRNP A1 in Castration-Resistant Prostate Cancer

Computer-Aided Discovery of Small Molecules Targeting the RNA Splicing Activity of hnRNP A1 in Castration-Resistant Prostate Cancer

The heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a versatile RNA-binding protein playing a critical role in alternative pre-mRNA splicing regulation in cancer. Emerging data have implicated hnRNP A1 as a central player in a splicing regulatory circuit involving its direct transcriptional...

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Bibliographic Details
Main Authors: Lavinia A. Carabet, Eric Leblanc, Nada Lallous, Helene Morin, Fariba Ghaidi, Joseph Lee, Paul S. Rennie, Artem Cherkasov
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
hnRNP A1
alternative splicing
castration-resistant prostate cancer
computer-aided drug discovery
small molecule inhibitors
protein–RNA interactions
Online Access:https://www.mdpi.com/1420-3049/24/4/763

Internet

https://www.mdpi.com/1420-3049/24/4/763

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