Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice

Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice

Wnt/β-catenin is involved in every aspect of embryonic development and in the pathogenesis of many human diseases, and is also implicated in organ fibrosis. However, the role of β-catenin-mediated signaling on liver fibrosis remains unclear. To explore this issue, the effects of PRI-724, a selective...

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Bibliographic Details
Main Authors: Yosuke Osawa, Keisuke Oboki, Jun Imamura, Ekumi Kojika, Yukiko Hayashi, Tsunekazu Hishima, Toshiji Saibara, Futoshi Shibasaki, Michinori Kohara, Kiminori Kimura
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:EBioMedicine
Subjects:
Liver
Fibrosis
Beta-catenin
Hepatic stellate cell
Macrophage***
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415301742

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http://www.sciencedirect.com/science/article/pii/S2352396415301742

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