Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist

Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist

Objective: Glucagon-like peptide-1 and glucagon receptor (GLP-1R/GCGR) co-agonism can maximise weight loss and improve glycaemic control in type 2 diabetes and obesity. In this study, we investigated the cellular and metabolic effects of modulating the balance between G protein and β-arrestin-2 recr...

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Bibliographic Details
Main Authors: Phil Pickford, Maria Lucey, Roxana-Maria Rujan, Emma Rose McGlone, Stavroula Bitsi, Fiona B. Ashford, Ivan R. Corrêa, David J. Hodson, Alejandra Tomas, Giuseppe Deganutti, Christopher A. Reynolds, Bryn M. Owen, Tricia M. Tan, James Minnion, Ben Jones, Stephen R. Bloom
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Metabolism
Subjects:
GLP-1
Glucagon
Oxyntomodulin
Biased agonism
Partial agonism
β-arrestin
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821000879

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http://www.sciencedirect.com/science/article/pii/S2212877821000879

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