Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

We analyzed aging parameters using a mechanistic target of rapamycin (mTOR) hypomorphic mouse model. Mice with two hypomorphic (mTORΔ/Δ) alleles are viable but express mTOR at approximately 25% of wild-type levels. These animals demonstrate reduced mTORC1 and mTORC2 activity and exhibit an approxim...

Full description

Bibliographic Details
Main Authors: J. Julie Wu, Jie Liu, Edmund B. Chen, Jennifer J. Wang, Liu Cao, Nisha Narayan, Marie M. Fergusson, Ilsa I. Rovira, Michele Allen, Danielle A. Springer, Cory U. Lago, Shuling Zhang, Wendy DuBois, Theresa Ward, Rafael deCabo, Oksana Gavrilova, Beverly Mock, Toren Finkel
Format: Article
Language:English
Published: Elsevier 2013-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713003926

Internet

http://www.sciencedirect.com/science/article/pii/S2211124713003926

Similar Items