Potential benefits of sequential inhibitor-mutagen treatments of RNA virus infections.
Lethal mutagenesis is an antiviral strategy consisting of virus extinction associated with enhanced mutagenesis. The use of non-mutagenic antiviral inhibitors has faced the problem of selection of inhibitor-resistant virus mutants. Quasispecies dynamics predicts, and clinical results have confirmed,...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2009-11-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC2771356?pdf=render |