Transcription-associated R-loop formation across the human FMR1 CGG-repeat region.

Transcription-associated R-loop formation across the human FMR1 CGG-repeat region.

Expansion of a trinucleotide (CGG) repeat element within the 5' untranslated region (5'UTR) of the human FMR1 gene is responsible for a number of heritable disorders operating through distinct pathogenic mechanisms: gene silencing for fragile X syndrome (>200 CGG) and RNA toxic gain-of-...

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Bibliographic Details
Main Authors: Erick W Loomis, Lionel A Sanz, Frédéric Chédin, Paul J Hagerman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-04-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3990486?pdf=render

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http://europepmc.org/articles/PMC3990486?pdf=render

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