Transcription-associated R-loop formation across the human FMR1 CGG-repeat region.
Expansion of a trinucleotide (CGG) repeat element within the 5' untranslated region (5'UTR) of the human FMR1 gene is responsible for a number of heritable disorders operating through distinct pathogenic mechanisms: gene silencing for fragile X syndrome (>200 CGG) and RNA toxic gain-of-...
Main Authors: | Erick W Loomis, Lionel A Sanz, Frédéric Chédin, Paul J Hagerman |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-04-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC3990486?pdf=render |
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