Dexamethasone premedication suppresses vaccine-induced immune responses against cancer

Dexamethasone premedication suppresses vaccine-induced immune responses against cancer

Glucocorticosteroids (GCS) have an established role in oncology and are administered to cancer patients in routine clinical care and in drug development trials as co-medication. Given their strong immune-suppressive activity, GCS may interfere with immune-oncology drugs. We are developing a therapeu...

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Bibliographic Details
Main Authors: Mathias Vormehr, Sophie Lehar, Lena M. Kranz, Siri Tahtinen, Yoko Oei, Vincent Javinal, Lélia Delamarre, Kerstin C. Walzer, Mustafa Diken, Sebastian Kreiter, Ira Mellman, Ugur Sahin, Jill M. Schartner, Özlem Türeci
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
glucocorticosteroids
dexamethasone
t-cell vaccine
rna vaccine
cancer immunotherapy
t-cell priming
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1758004

Internet

http://dx.doi.org/10.1080/2162402X.2020.1758004

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