Cerebral mGluR5 availability contributes to elevated sleep need and behavioral adjustment after sleep deprivation

Cerebral mGluR5 availability contributes to elevated sleep need and behavioral adjustment after sleep deprivation

Increased sleep time and intensity quantified as low-frequency brain electrical activity after sleep loss demonstrate that sleep need is homeostatically regulated, yet the underlying molecular mechanisms remain elusive. We here demonstrate that metabotropic glutamate receptors of subtype 5 (mGluR5)...

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Bibliographic Details
Main Authors: Sebastian C Holst, Alexandra Sousek, Katharina Hefti, Sohrab Saberi-Moghadam, Alfred Buck, Simon M Ametamey, Milan Scheidegger, Paul Franken, Anke Henning, Erich Seifritz, Mehdi Tafti, Hans-Peter Landolt
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-10-01
Series:eLife
Subjects:
PET-MRS
molecular imaging
working memory
Y-maze
plasticity marker
fragile X syndrome
Online Access:https://elifesciences.org/articles/28751

Internet

https://elifesciences.org/articles/28751

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