The genetic architecture of plasma kynurenine includes cardiometabolic disease mechanisms associated with the SH2B3 gene

The genetic architecture of plasma kynurenine includes cardiometabolic disease mechanisms associated with the SH2B3 gene

Abstract Inflammation increases the risk of cardiometabolic disease. Delineating specific inflammatory pathways and biomarkers of their activity could identify the mechanistic underpinnings of the increased risk. Plasma levels of kynurenine, a metabolite involved in inflammation, associates with car...

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Bibliographic Details
Main Authors: Minoo Bagheri, Chuan Wang, Mingjian Shi, Ali Manouchehri, Katherine T. Murray, Matthew B. Murphy, Christian M. Shaffer, Kritika Singh, Lea K. Davis, Gail P. Jarvik, Ian B. Stanaway, Scott Hebbring, Muredach P. Reilly, Robert E. Gerszten, Thomas J. Wang, Jonathan D. Mosley, Jane F. Ferguson
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-95154-9

Internet

https://doi.org/10.1038/s41598-021-95154-9

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