Heart failure clinical care analysis uncovers risk reduction opportunities for preserved ejection fraction subtype

by Rebecca T. Levinson, Nataraja Sarma Vaitinidin, Eric Farber-Eger, Dan M. Roden, Thomas A. Lasko, Quinn S. Wells, Jonathan D. Mosley
Published 2021-09-01

Integrating EMR-linked and in vivo functional genetic data to identify new genotype-phenotype associations.

by Jonathan D Mosley, Sara L Van Driest, Peter E Weeke, Jessica T Delaney, Quinn S Wells, Lisa Bastarache, Dan M Roden, Josh C Denny
Published 2014-01-01

Comparison of HLA allelic imputation programs.

by Jason H Karnes, Christian M Shaffer, Lisa Bastarache, Silvana Gaudieri, Andrew M Glazer, Heidi E Steiner, Jonathan D Mosley, Simon Mallal, Joshua C Denny, Elizabeth J Phillips, Dan M Roden
Published 2017-01-01

Identifying genetically driven clinical phenotypes using linear mixed models

by Jonathan D. Mosley, John S. Witte, Emma K. Larkin, Lisa Bastarache, Christian M. Shaffer, Jason H. Karnes, C. Michael Stein, Elizabeth Phillips, Scott J. Hebbring, Murray H. Brilliant, John Mayer, Zhan Ye, Dan M. Roden, Joshua C. Denny
Published 2016-04-01

Clinical and genetic associations with prostacyclin response in pulmonary arterial hypertension

by Stephen J. Halliday, Meng Xu, Timothy E. Thayer, Jonathan D. Mosley, Quanhu Sheng, Fei Ye, Eric H. Farber-Eger, Meredith E. Pugh, Ivan R. Robbins, Tufik R. Assad, James D. West, Evan L. Brittain, Anna R. Hemnes
Published 2018-09-01

Relationship between very low low-density lipoprotein cholesterol concentrations not due to statin therapy and risk of type 2 diabetes: A US-based cross-sectional observational stu...

by QiPing Feng, Wei-Qi Wei, Cecilia P Chung, Rebecca T Levinson, Alexandra C Sundermann, Jonathan D Mosley, Lisa Bastarache, Jane F Ferguson, Nancy J Cox, Dan M Roden, Joshua C Denny, MacRae F Linton, Digna R Velez Edwards, C Michael Stein
Published 2018-08-01

The genetic architecture of plasma kynurenine includes cardiometabolic disease mechanisms associated with the SH2B3 gene

by Minoo Bagheri, Chuan Wang, Mingjian Shi, Ali Manouchehri, Katherine T. Murray, Matthew B. Murphy, Christian M. Shaffer, Kritika Singh, Lea K. Davis, Gail P. Jarvik, Ian B. Stanaway, Scott Hebbring, Muredach P. Reilly, Robert E. Gerszten, Thomas J. Wang, Jonathan D. Mosley, Jane F. Ferguson
Published 2021-08-01

Clinical laboratory test-wide association scan of polygenic scores identifies biomarkers of complex disease

by Jessica K. Dennis, Julia M. Sealock, Peter Straub, Younga H. Lee, Donald Hucks, Ky’Era Actkins, Annika Faucon, Yen-Chen Anne Feng, Tian Ge, Slavina B. Goleva, Maria Niarchou, Kritika Singh, Theodore Morley, Jordan W. Smoller, Douglas M. Ruderfer, Jonathan D. Mosley, Guanhua Chen, Lea K. Davis
Published 2021-01-01

Lossless integration of multiple electronic health records for identifying pleiotropy using summary statistics

by Ruowang Li, Rui Duan, Xinyuan Zhang, Thomas Lumley, Sarah Pendergrass, Christopher Bauer, Hakon Hakonarson, David S. Carrell, Jordan W. Smoller, Wei-Qi Wei, Robert Carroll, Digna R. Velez Edwards, Georgia Wiesner, Patrick Sleiman, Josh C. Denny, Jonathan D. Mosley, Marylyn D. Ritchie, Yong Chen, Jason H. Moore
Published 2021-01-01

Mechanistic phenotypes: an aggregative phenotyping strategy to identify disease mechanisms using GWAS data.

by Jonathan D Mosley, Sara L Van Driest, Emma K Larkin, Peter E Weeke, John S Witte, Quinn S Wells, Jason H Karnes, Yan Guo, Lisa Bastarache, Lana M Olson, Catherine A McCarty, Jennifer A Pacheco, Gail P Jarvik, David S Carrell, Eric B Larson, David R Crosslin, Iftikhar J Kullo, Gerard Tromp, Helena Kuivaniemi, David J Carey, Marylyn D Ritchie, Josh C Denny, Dan M Roden
Published 2013-01-01

Proteomic profiling reveals biomarkers and pathways in type 2 diabetes risk

by Debby Ngo, Mark D. Benson, Jonathan Z. Long, Zsu-Zsu Chen, Ruiqi Wang, Anjali K. Nath, Michelle J. Keyes, Dongxiao Shen, Sumita Sinha, Eric Kuhn, Jordan E. Morningstar, Xu Shi, Bennet D. Peterson, Christopher Chan, Daniel H. Katz, Usman A. Tahir, Laurie A. Farrell, Olle Melander, Jonathan D. Mosley, Steven A. Carr, Ramachandran S. Vasan, Martin G. Larson, J. Gustav Smith, Thomas J. Wang, Qiong Yang, Robert E. Gerszten
Published 2021-03-01

Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer

by Thomas J. Hoffmann, Michael N. Passarelli, Rebecca E. Graff, Nima C. Emami, Lori C. Sakoda, Eric Jorgenson, Laurel A. Habel, Jun Shan, Dilrini K. Ranatunga, Charles P. Quesenberry, Chun R. Chao, Nirupa R. Ghai, David Aaronson, Joseph Presti, Tobias Nordström, Zhaoming Wang, Sonja I. Berndt, Stephen J. Chanock, Jonathan D. Mosley, Robert J. Klein, Mridu Middha, Hans Lilja, Olle Melander, Mark N. Kvale, Pui-Yan Kwok, Catherine Schaefer, Neil Risch, Stephen K. Van Den Eeden, John S. Witte
Published 2017-01-01

A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers

by Jonathan D. Mosley, QiPing Feng, Quinn S. Wells, Sara L. Van Driest, Christian M. Shaffer, Todd L. Edwards, Lisa Bastarache, Wei-Qi Wei, Lea K. Davis, Catherine A. McCarty, Will Thompson, Christopher G. Chute, Gail P. Jarvik, Adam S. Gordon, Melody R. Palmer, David R. Crosslin, Eric B. Larson, David S. Carrell, Iftikhar J. Kullo, Jennifer A. Pacheco, Peggy L. Peissig, Murray H. Brilliant, James G. Linneman, Bahram Namjou, Marc S. Williams, Marylyn D. Ritchie, Kenneth M. Borthwick, Shefali S. Verma, Jason H. Karnes, Scott T. Weiss, Thomas J. Wang, C. Michael Stein, Josh C. Denny, Dan M. Roden
Published 2018-08-01

Phenome Wide Association Studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index

by Robert Michael Cronin, Julie R Field, Yuki eBradford, Christian M Shaffer, Robert J Carroll, Jonathan D Mosley, Lisa eBastarache, Todd L Edwards, Scott J Hebbring, Simon eLin, Lucia A Hindorff, Paul K Crane, Sarah ePendergrass, Marylyn D Ritchie, Dana C Crawford, Jyotishman ePathak, Suzette eBielinski, David S Carrell, David R Crosslin, David H Ledbetter, David J Carey, Gerard eTromp, Marc S Williams, Eric B Larson, Gail P Jarvik, Peggy L Peissig, Murray H Brilliant, Catherine Anne McCarty, Christopher G Chute, Iftikhar J Kullo, Erwin eBottinger, Rex eChisholm, Maureen E Smith, Dan M Roden, Joshua C Denny
Published 2014-08-01