Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure

Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure

Objective: Insulin signalling via phosphoinositide 3-kinase (PI3K) requires PIK3R1-encoded regulatory subunits. C-terminal PIK3R1 mutations cause SHORT syndrome, as well as lipodystrophy and insulin resistance (IR), surprisingly without fatty liver or metabolic dyslipidaemia. We sought to investigat...

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Bibliographic Details
Main Authors: Albert Kwok, Ilona Zvetkova, Sam Virtue, Ineke Luijten, Isabel Huang-Doran, Patsy Tomlinson, David A. Bulger, James West, Steven Murfitt, Julian Griffin, Rafeah Alam, Daniel Hart, Rachel Knox, Peter Voshol, Antonio Vidal-Puig, Jørgen Jensen, Stephen O'Rahilly, Robert K. Semple
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Molecular Metabolism
Subjects:
Insulin resistance
Diabetes
Lipotoxicity
PI 3-Kinase
p85
Pik3r1
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820300946

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http://www.sciencedirect.com/science/article/pii/S2212877820300946

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