Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation

Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation

Abstract Background Histone deacetylase inhibitors (HDACi) suppress cytokine production in immune and stromal cells of patients with rheumatoid arthritis (RA). Here, we investigated the effects of the HDACi givinostat (ITF2357) on the transcriptional and post-transcriptional regulation of inflammato...

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Bibliographic Details
Main Authors: Chiara Angiolilli, Pawel A. Kabala, Aleksander M. Grabiec, Marzia Rossato, Wi S. Lai, Gianluca Fossati, Paolo Mascagni, Christian Steinkühler, Perry J. Blackshear, Kris A. Reedquist, Dominique L. Baeten, Timothy R. D. J. Radstake
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Fibroblast-like synoviocytes
Inflammation
mRNA stability
Tristetraprolin
Histone deacetylase inhibitor
Online Access:http://link.springer.com/article/10.1186/s13075-018-1638-4

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http://link.springer.com/article/10.1186/s13075-018-1638-4

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