Gene Modification and Three‐Dimensional Scaffolds as Novel Tools to Allow the Use of Postnatal Thymic Epithelial Cells for Thymus Regeneration Approaches

Gene Modification and Three‐Dimensional Scaffolds as Novel Tools to Allow the Use of Postnatal Thymic Epithelial Cells for Thymus Regeneration Approaches

Abstract Defective functionality of thymic epithelial cells (TECs), due to genetic mutations or injuring causes, results in altered T‐cell development, leading to immunodeficiency or autoimmunity. These defects cannot be corrected by hematopoietic stem cell transplantation (HSCT), and thymus transpl...

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Bibliographic Details
Main Authors: Ileana Bortolomai, Monica Sandri, Elena Draghici, Elena Fontana, Elisabetta Campodoni, Genni Enza Marcovecchio, Francesca Ferrua, Laura Perani, Antonello Spinelli, Tamara Canu, Marco Catucci, Tiziano Di Tomaso, Lucia Sergi Sergi, Antonio Esposito, Angelo Lombardo, Luigi Naldini, Anna Tampieri, Georg A. Hollander, Anna Villa, Marita Bosticardo
Format: Article
Language:English
Published: Wiley 2019-10-01
Series:Stem Cells Translational Medicine
Subjects:
3D collagen scaffolds
Lentiviral vector
Thymic epithelial cells
Thymic regeneration
Online Access:https://doi.org/10.1002/sctm.18-0218

Internet

https://doi.org/10.1002/sctm.18-0218

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